Anti-Anthrax Protective Antigen (Intermediate Domain)
Product Sizes
20µg
£500.00
12-8191-20UG
0.1 mg
£856.00
12-8191-0.1MG
About this Product
- SKU:
- 12-8191
- Additional Names:
- Anthrax Protective Antigen
- Clonality:
- Polyclonal
- Extra Details:
- Specificity: Rabbit Anti-Anthrax Protective Antigen (Anthrax PA) recognizes an epitope in the intermediate domain of Anthrax PA. This polyclonal antibody was purified using affinity chromatography. Background: Anthrax infection is initiated by the inhalation; ingestion; or cutaneous contact with Bacillus anthracis endospores. B. anthracis produces three polypeptides that comprise the anthrax toxin: protective antigen (PA); lethal factor (LF); and edema factor (EF)1;2. PA binds to two related proteins on the cell surface; these are termed tumor epithelial marker 8 (TEM8)/anthrax toxin receptor (ATR)3 and capillary morphogenesis protein 2 (CMG2);4 although it is still unclear which is physiologically relevant. Following PA binding to its receptor; PA is cleaved into two fragments by a furin-like protease. The bound fragment binds both LF and EF; the resulting complex is then endocytosed which allows the translocation of LF and EF into the cytoplasm. These toxins are usually sufficient to cause rapid cell death; and often the death of the organism.
- Host:
- Rabbit
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- This polyclonal antibody is stable for at least one week when stored at 2-8[o]C. For long term storage; aliquotin woring volumes without diluing and store at 20[o]C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:download_pdf.php
