Anti-Rotavirus (Clone: RV6-26)
Product Sizes
100 µg
£649.00
12-8136-100UG
About this Product
- SKU:
- 12-8136
- translate.label.attr.clone:
- RV6-26
- Clonality:
- Monoclonal
- Extra Details:
- Reactivity Species : Rotavirus-Virus Expression Host : HEK-293 Endotoxin Level :≤ 1.0 EU/mg as determined by the LAL method. Specificity : RV6-26 activity is directed against a quaternary epitope on VP6. This human monoclonal antibody RV6-26 binds at the viral RNA release pore in the DLP and is able to neutralize RV by inhibiting transcription. Structural data suggest steric hindrance inhibits the transcriptional pore. Background : Rotaviruses (RV) are double-stranded; non-enveloped; icosahedral RNA viruses in the Reoviridae family that cause severe dehydrating diarrhea in infants and children. RV particles are composed of concentric viral protein (VP) layers. The triple-layered particle has an inner capsid layer (VP2); an intermediate capsid layer (VP6); and an outer capsid layer (VP7; VP4). The transcriptionally active double-layered particle (DLP) consists of VP2 and VP6. VP6 is the most antigenic RV protein in humans. The antibody VH146 gene segment is the site of primary interaction with VP65.
- Host:
- Human
- Immunogen:
- Human Mab RV6-26 was sequenced from RV-specific B cells isolated from the blood of healthy adult donors or RV-infected infants or adults
- Isotype:
- Human IgG
- Purification:
- >=95% monomer by analytical SEC
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Functional grade preclinical antibodies may be stored sterile as received at 2-8[o]C for up to one year. For longer term storage; aseptically aliquot in working volumes without diluting and store at >= -70[o]C. Avoid Repeated Freeze Thaw Cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Viral Particles
- Manufacturer's Data Sheet:download_pdf.php
