Anti-Rotavirus (Clone: RV6-25)
Product Sizes
100 µg
£649.00
12-8135-100UG
About this Product
- SKU:
- 12-8135
- translate.label.attr.clone:
- RV6-25
- Clonality:
- Monoclonal
- Extra Details:
- Reactivity Species : Rotavirus-Virus Expression Host : HEK-293 Endotoxin Level :≤ 1.0 EU/mg as determined by the LAL method Specificity : RV6-25 activity is directed against the apical surface of the VP6 head domain. RV6-25 and RV6-26 are encoded by the same heavy chain variable segment; but unlike RV6-26; RV6-25 is unable to inhibit RV. Three-dimensional structural analyses of DLP: Fab complexes show that RV6-25 Fab molecules attach to the tops of VP6 trimers; at one VP6 subunit; with the epitope positioned along the edge and in close contact with the VP6 surface loop. The RV6-25 Fab protrudes from the VP6 trimers and extends away from the viral surface in a regular pattern depending on the position of the VP6 trimer in the VP6 layer1. Additionally; RV6-25 binds to the apical surface of the DLP VP6 head domain and does not obstruct the transcription pore. The Fab binds to epitopes on the distinct P; P€²; T; T€²; or D VP6 trimers. Background : Rotaviruses (RV) are double-stranded; non-enveloped; icosahedral RNA viruses in the Reoviridae family that cause severe dehydrating diarrhea in infants and children. RV particles are composed of concentric viral protein (VP) layers. The triple-layered particle has an inner capsid layer (VP2); an intermediate capsid layer (VP6); and an outer capsid layer (VP7; VP4). The transcriptionally active double-layered particle (DLP) consists of VP2 and VP6. VP6 is the most antigenic RV protein in humans.
- Host:
- Human
- Immunogen:
- Human Mab RV6-25 was sequenced from RV-specific B cells isolated from the blood of healthy adult donors or RV-infected infants or adults.
- Isotype:
- Human IgG
- Purification:
- >=95% monomer by analytical SEC
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Functional grade preclinical antibodies may be stored sterile as received at 2-8[o]C for up to one year. For longer term storage; aseptically aliquot in working volumes without diluting and store at >= -70[o]C. Avoid Repeated Freeze Thaw Cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Viral Particles
- Manufacturer's Data Sheet:download_pdf.php
