Anti-Ross River Virus (Clone: RRV-19)
Product Sizes
100 µg
£649.00
12-8134-100UG
About this Product
- SKU:
- 12-8134
- Additional Names:
- RRV
- translate.label.attr.clone:
- RRV-19
- Clonality:
- Monoclonal
- Extra Details:
- Reactivity Species : Ross River-Virus Expression Host : HEK-293 Product Concentration : ‰¥ 5.0 mg/ml Specificity : RRV-19 activity is directed against the B domain of the E2 protein and was determined by alanine scanning mutagenesis using cell-surface expression of RRV proteins and flow cytometric screening were used to identify critical binding residues in the E2 glycoprotein. Loss of binding occurs when residue 221 on the B domain of the E2 protein is mutated. Furthermore; clone RRV-19 is capable of neutralizing virus in both pre- and post-attachment neutralization assays. Antigen Distribution : Ross River Virus E2 is expressed on the surface of RRV. Ross River Virus (RRV) is a mosquito-borne; positive sense; single-stranded virus endemic to Australia and Papua New Guinea that belongs to the arthritogenic group of alphaviruses. The mature glycoprotein is composed of E1 and E2 envelope proteins in a heterodimer; expressed as a trimeric spike on the virus surface . RRV-19 is of the IgG1 isotype and is capable of binding and neutralizing prototype strain RRV T48 as well as clinical isolate strains PW7; SN11; PW14; 2897601; and O'Regan in focus reduction neutralization tests.
- Host:
- Human
- Immunogen:
- A panel of human mAbs were sequenced; including RRV-19; was generated from the peripheral blood mononuclear cells of two donors who were naturally infected with RRV
- Isotype:
- Human IgG1
- Purification:
- >=95% monomer by analytical SEC
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Functional grade preclinical antibodies may be stored sterile as received at 2-8[o]C for up to one year. For longer term storage; aseptically aliquot in working volumes without diluting and store at >= -70[o]C. Avoid Repeated Freeze Thaw Cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Viral Particles
- Manufacturer's Data Sheet:download_pdf.php
