Anti-Respiratory Syncytial Virus (Clone: RSV-17E10)
Product Sizes
100 µg
£649.00
12-8118-100UG
About this Product
- SKU:
- 12-8118
- Additional Names:
- RSV; Orthopneumovirus
- translate.label.attr.clone:
- RSV-17E10
- Clonality:
- Monoclonal
- Extra Details:
- Reactivity Species : Respiratory Syncytial-Virus Expression Host : HEK-293 Endotoxin Level :≤ 1.0 EU/mg as determined by the LAL method Specificity : RSV-17E10 activity is directed against antigenic site IV of the RSV and hMPV fusion (F) proteins and binds to pre- and post-fusion F proteins of RSV A strain A2 and RSV B strain 18537. Antibody RSV-17E10 is also capable of neutralizing RSV A2; RSV Long viruses (subgroup A); RSV 18537 B; and RSV WV/401R viruses (subgroup B). Competition-binding assay shows that RSV-17E10 targets antigenic site IV. The mode of action is independent of R429. RSV-17E10 is cross-reactive with hMPV F at antigenic site IV and neutralizes hMPV better than RSV. Cross-neutralization of RSV and hMPV is associated with recognition of the G430 and I432 residues; which are shared between RSV and hMPV F proteins. RSV-17E10 binds at a unique ~56° tilt; which may be a determinant of cross-reactivity with hMPV F.
- Host:
- Human
- Immunogen:
- Human donors targeting the post-fusion RSV F protein using human hybridoma technology
- Isotype:
- Human IgG1
- Purification:
- >=95% monomer by analytical SEC
- Shipping Conditions:
- Blue Ice
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Viral Particles
- Manufacturer's Data Sheet:download_pdf.php
