Anti-Respiratory Syncytial Virus (Clone: RSV-14N4)
Product Sizes
100 µg
£649.00
12-8117-100UG
About this Product
- SKU:
- 12-8117
- Additional Names:
- RSV; Orthopneumovirus;
- translate.label.attr.clone:
- RSV-14N4
- Clonality:
- Monoclonal
- Extra Details:
- Reactivity Species : Respiratory Syncytial‹…Virus Expression Host : HEK-293 Endotoxin Level :≤ 1.0 EU/mg as determined by the LAL method Specificity : RSV-14N4 activity is directed against antigenic site II of the RSV fusion (F) protein. RSV-14N4 readily competes with clone RSV-12I1 on post-fusion F; but the competition is less pronounced on prefusion F. A plaque reduction neutralization assay showed RSV-14N4 is capable of neutralizing RSV strain A2. By ELISA RSV-14N4 binds to both prefusion and post-fusion F proteins with equal affinity. Competition-binding studies showed that RSV-14N4 targets antigenic site II; which is the target of palivizumab; an antiviral monoclonal antibody used as a prophylactic treatment. Saturation alanine scanning mutagenesis identified residues Asp263; Ile266; Asp269; and Lys271 as critical for 14N4 binding. Binding to antigenic site II was confirmed by x-ray crystallography and electron microscopy as well as by binding to scaffolded epitopes containing site II.
- Host:
- Human
- Immunogen:
- Human donors targeting the postfusion RSV F protein using human hybridoma technology
- Isotype:
- Human IgG1
- Purification:
- >=95% monomer by analytical SEC
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Functional grade preclinical antibodies may be stored sterile as received at 2-8[o]C for up to one year. For longer term storage; aseptically aliquot in working volumes without diluting and store at >= -70[o]C. Avoid Repeated Freeze Thaw Cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Viral Particles
- Manufacturer's Data Sheet:download_pdf.php
