Anti-Respiratory Syncytial Virus (Clone: RSV-12I1)
Product Sizes
100 µg
£649.00
12-8116-100UG
About this Product
- SKU:
- 12-8116
- Additional Names:
- RSV; Orthopneumovirus
- translate.label.attr.clone:
- RSV-12I1
- Clonality:
- Monoclonal
- Extra Details:
- Reactivity Species : Respiratory Syncytial‹…Virus Expression Host : HEK-293 Endotoxin Level :≤ 1.0 EU/mg as determined by the LAL method Specificity : RSV-12I1 activity is directed against antigenic site II of the RSV fusion (F) protein. Clone RSV-12I1 did bind to both pre- and post-fusion F protein in an ELISA binding assay; favoring the post-fusion conformation. Competition-binding studies showed that RSV-12I1 targets antigenic site II; which is the target of palivizumab; an antiviral monoclonal antibody licensed as a prophylactic treatment. RSV-12I1 readily competed with RSV-14N4 on post-fusion F; but the competition was less pronounced on pre-fusion F. RSV-12I1 also competed with palivizumab on post-fusion F in a palivizumab competition assay. Saturation alanine scanning mutagenesis identified residues Leu467 and Lys470 as critical for RSV-12I1 binding. Binding was not detected to scaffolded epitopes containing site II.
- Host:
- Human
- Immunogen:
- Human donors targeting the post-fusion RSV F protein using human hybridoma technology
- Isotype:
- Human IgG1
- Purification:
- >=95% monomer by analytical SEC
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Functional grade preclinical antibodies may be stored sterile as received at 2-8[o]C for up to one year. For longer term storage; aseptically aliquot in working volumes without diluting and store at >= -70[o]C. Avoid Repeated Freeze Thaw Cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Viral Particles
- Manufacturer's Data Sheet:download_pdf.php
