Recombinant Anti-Monkeypox L1 Antibody (Clone: MPXV-26)
Product Sizes
100 µg (mg/mL)
£649.00
12-8115-100UG
About this Product
- SKU:
- 12-8115
- Additional Names:
- MPXV
- translate.label.attr.clone:
- MPXV-26
- Clonality:
- Monoclonal
- Extra Details:
- Reactivity Species: Vaccinia;Variola;Cowpox;Monkeypox;Virus Expression Host: HEK-293 Endotoxin Level:≤ 1.0 EU/mg as determined by the LAL method Specificity: MPXV-26 is reactive against L1; an MV surface protein. Complementary screening approaches were used to identify orthopoxvirus-specific mAbs to MPXV; cowpox virus (CPXV); variola virus (VARV); and vaccinia virus (VACV). MPXV-26 is reactive to VACV antigen; CPXV lysate; VARV antigen and lysate; but not MPXV lysate. MPXV-26 binds to VACV and VARV purified antigens and CPXV virus-infected cell lysate but not VACV and MPXV cell lysates. MPXV-26 neutralizes VACV MV and MV plus complement (MV+C'); CPXV MV and MV+C'; and weakly neutralizes MPXV MV and MV+C'. With cocktail of anti-monkeypox mAbs; neutralization and cross-neutralization are more efficient than in individual assays5. These mAb mixes also provide protection against VACV in mice. While not completely protective on its own; MPXV-26 induces delayed morbidity and mortality in mice; and mixes that exclude MPXV-26 are less effective prophylactics.
- Host:
- Human
- Immunogen:
- MPXV-26 was generated from peripheral blood mononuclear cells obtained from donors who had recovered from naturally-occurring MPXV infection
- Isotype:
- Human IgG1
- Purification:
- >=95% monomer by analytical SEC
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Functional grade preclinical antibodies may be stored sterile as received at 2-8[o]C for up to one year. For longer term storage; aseptically aliquot in working volumes without diluting and store at >= -70[o]C. Avoid Repeated Freeze Thaw Cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies
- Manufacturer's Data Sheet:download_pdf.php
