Anti-Human TNF alpha (Adalimumab) Fc Muted
Product Sizes
100 µg
£760.00
12-8104-100UG
About this Product
- SKU:
- 12-8104
- Additional Names:
- DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha
- translate.label.attr.clone:
- D2E7
- Clonality:
- Monoclonal
- Extra Details:
- Expression Host : HEK-293 Pathogen Testing : To protect mouse colonies from infection by pathogens and to assure that experimental preclinical data is not affected by such pathogens; all of this recombinant biosimilar antibodies are tested and guaranteed to be negative for all pathogens in the IDEXX IMPACT I Mouse Profile. This non-therapeutic biosimilar antibody uses the same variable region sequence as the therapeutic antibody Adalimumab. Clone D2E7 binds to soluble TNF- alpha; but not to TNF- beta (lymphotoxin). This product is for research use only. Adalimumab is a research-grade monoclonal antibody that works by inactivating tumor necrosis factor-alpha (TNF-alpha). TNF-alpha is a 17.5 kD protein that mediates inflammation and immunity caused by the invasion of viruses; bacteria; and parasites by initiating a cascade of cytokines that increase vascular permeability; thus bringing macrophages and neutrophils to the site of infection. TNF-alpha secreted by the macrophage causes the blood to clot which provides containment of the infection. TNF-alpha inactivation has proven to be important in downregulating the inflammatory reactions associated with autoimmune diseases such as rheumatoid arthritis; psoriatic arthritis; ankylosing spondylitis; Crohn's disease; moderate to severe chronic psoriasis; and juvenile idiopathic arthritis. Adalimumab blocks the interaction with the p55 and p75 cell surface TNF receptors thus; neutralizing the biological function of TNF. Anti-Human TNF alpha (Adalimumab) utilizes the same variable regions from the therapeutic antibody Adalimumab making it ideal for research projects.
- Host:
- Human
- Immunogen:
- Human TNF alpha
- Isotype:
- Human IgG1k
- Purification:
- >95% by SDS-PAGE and HPLC
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Functional grade preclinical antibodies may be stored sterile as received at 2-8[o]C for up to one month. For longer term storage; aseptically aliquot in working volumes without diluting and store at -80[o]C. Avoid Repeated Freeze Thaw Cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:download_pdf.php
