Anti-Human CTLA-4 (Ipilimumab) Fc Muted
Product Sizes
100 µg
£760.00
12-8057-100UG
About this Product
- SKU:
- 12-8057
- Additional Names:
- CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3
- translate.label.attr.clone:
- MDX-010
- Clonality:
- Monoclonal
- Extra Details:
- Expression Host : HEK-293 Pathogen Testing : To protect mouse colonies from infection by pathogens and to assure that experimental preclinical data is not affected by such pathogens; all of this recombinant biosimilar antibodies are tested and guaranteed to be negative for all pathogens in the IDEXX IMPACT I Mouse Profile. This non-therapeutic biosimilar antibody uses the same variable region sequence as the therapeutic antibody Ipilimumab. Ipilimumab binds to Human CTLA-4. This product is for research use only. Cytotoxic T-lymphocyteassociated antigen 4 (CTLA-4) is a protein receptor that serves as an immune checkpoint and down-regulates the immune system. CTLA-4 is constitutively expressed in regulatory T cells but is only upregulated in conventional T cells following activation. Many cancers; including Melanoma; are associated with CTLA-4 upregulation because the body's ability to recognize and destroy cancer cells is hampered by an inhibitory mechanism. Ipilimumab targets CTLA-4 and works by turning off this inhibitory mechanism and; thus; enhances the body's own immune response against cancer cells.€2 Emerging research suggests that combined blockade of PD-1 and CTLA-4; with Nivolumab and Ipilimumab respectively; could produce greater antitumor activity than blockade of either pathway alone.1 This cost-effective; research-grade Anti-Human CTLA-4 (Ipilimumab) utilizes the same variable regions from the therapeutic antibody Ipilimumab making it ideal for research projects.
- Host:
- Human
- Immunogen:
- Human CTLA-4
- Isotype:
- Human IgG1k
- Purification:
- >=95% monomer by analytical SEC
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Functional grade biosimilar antibodies may be stored sterile as received at 2-8[o]C for up to one month. For longer term storage; aseptically aliquot in working volumes without diluting and store at -80[o]C. Avoid Repeated Freeze Thaw Cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:download_pdf.php
