Anti-Human CD194 (CCR4) (Mogamulizumab) Fc Muted
Product Sizes
100 µg
£760.00
12-8022-100UG
About this Product
- SKU:
- 12-8022
- Additional Names:
- CD194; CKR-4; CCR-4; CCR4; K5-5
- translate.label.attr.clone:
- KW-0761
- Clonality:
- Monoclonal
- Extra Details:
- Expression Host : HEK-293 Pathogen Testing : To protect mouse colonies from infection by pathogens and to assure that experimental preclinical data is not affected by such pathogens; all of this recombinant biosimilar antibodies are tested and guaranteed to be negative for all pathogens in the IDEXX IMPACT I Mouse Profile. This non-therapeutic biosimilar antibody uses the same variable region sequence as the therapeutic antibody Mogamulizumab. Clone KW-0761 recognizes human CD194 (CCR4). This product is for research use only. Clone KW-0761 (Mogamulizumab) is a research-grade; afucosylated; humanized monoclonal antibody generated from mouse anti-CCR4 mAb7 that targets human CCR4.1 CC chemokine receptor type 4 (CCR4) is a protein that belongs to the G protein-coupled receptor family and is a receptor for a variety of CC chemokines including MCP-1; MIP-1; RANTES; TARC; and Macrophage-derived chemokine. Chemokines are involved in the development; homeostasis; and function of the immune system and are known to regulate cell trafficking of various types of leukocytes. In a 2018 Phase I clinical trial; Mogamulizumab was found to decrease the number of HTLV-1infected cells and the levels of inflammatory markers related to HTLV-1Associated Myelopathy.3
- Host:
- Human
- Immunogen:
- Humanization of mouse anti-CCR4 mAb7.
- Isotype:
- Human IgG1k
- Purification:
- >=95% monomer by analytical SEC
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Functional grade biosimilar antibodies may be stored sterile as received at 2-8[o]C for up to one month. For longer term storage; aseptically aliquot in working volumes without diluting and store at -80[o]C. Avoid Repeated Freeze Thaw Cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:download_pdf.php
