Anti-Human HER-2 (Trastuzumab) PE
Product Sizes
50 µg
£628.00
12-8006-50UG
About this Product
- SKU:
- 12-8006
- Additional Names:
- ErbB-2; NEU; NGL; HER2; TKR1; CD340; MLN 19; HER-2/neu
- translate.label.attr.clone:
- 4D5-8
- Clonality:
- Monoclonal
- Extra Details:
- Expression Host : HEK-293 This non-therapeutic biosimilar antibody uses the same variable region sequence as the therapeutic antibody Trastuzumab. Clone 4D5-8 recognizes human erbB-2. This product is for research use only. Trastuzumab is a monoclonal antibody targeting HER2; a 185 kDa transmembrane glycoprotein that contains an extracellular domain and intracellular tyrosine kinase activity. When it is functioning normally; the HER2 pathway supports cell growth and division. On the other hand; the over expression of HER2 propels cell growth beyond its typical range. This overexpression is associated with some cancers; namely breast and stomach; in which the HER2 protein can be expressed up to 100 times more than in typical cells. Trastuzumab induces an immune-mediated response that triggers the internalization and downregulation of HER2 making it an excellent target for immunotherapy. Several clinical studies are under way which show that anti-HER-2/neu antibodies inhibit the growth and proliferation of these tumor cells In vitro as well as In vivo.
- Host:
- Human
- Immunogen:
- Human epidermoid carcinoma cells (A431) over-expressing EGFR.
- Isotype:
- Human IgG1k
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- This R-phycoerythrin (R-PE) conjugate is stable when stored at 2-8[o]C. Do not freeze.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:download_pdf.php
