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Antibodies

Anti-CTX-M (C11) rabbit mAb

Product Sizes
200ul
£1021.00
12-4349-200UL
About this Product
SKU:
12-4349
Clonality:
Monoclonal
Conjugate:
Unconjugated
Extra Details:
CTX-M-type enzymes are a group of class A extended-spectrum beta-lactamases (ESBLs) that are rapidly spreading among Entrobacteriaeae worldwide (1). CTX-M-type β-lactamases; originally found in Kluyvera spp.; shows hydrolysis activity on ceflaxime and its gene spreads via plasmid. Since their discovery in Europe in the early 1980s; they have spread worldwide and are now endemic in Enterobacterales isolated from both hospital-associated and community-acquired infections; including urinary tract infections and bloodstream infections (2). Especially; poor sanitary conditions are more likely to result in the transfer of CTX-M-type enzymes in the Enterobacterales between animals; humans; and living environment. As a result; they are a global public health concern. In the past; TEM- and SHV-type ESBLs were the predominant families of ESBLs. CTX-M-type enzymes have increased since 2000; and today the most commonly found ESBL type with the CTX-M-15 variant dominating worldwide; followed in prevalence CTX-M-14; and CTX-M-27 is emerging in certain parts of the world (3). Presently; more than 50 allelic variants are known; clustered in six sub-lineages or groups.
Format:
Purified
Host:
Rabbit
Immunogen:
Recombinant CTX-M antigen
Isotype:
Anti-Rabbit IgG
Purification:
Protein A
Shipping Conditions:
Blue Ice
Storage Conditions:
Store at-20[o]C. Avoid repeated freeze and thaw cycles.
Supplier:
Abeomics
Type:
Antibodies:Monoclonal Antibody
Fig 2 : Detection of CTX-M protein by lateral flow immunoassay using colloidal gold conjugated anti-CTX-M (C11) rabbit mAb (Cat. 12-4349) and goat polyclonal antibody with multiple antigen recognition. The recombinant CTX-M 14 protein produced by E coli was used as standard antigen. Its limit of detection was 0.8 ng/mL.
Fig. 3: Western blot analysis of recombinant CTX-M subtypes with anti-CTX-M (C11) rabbit mAb at 0.1 ug/mL (Cat. 12-4349). HRP-conjugated goat anti rabbit antibody was used as the secondary antibody. Cross-reactivity of the antibody was confirmed by the colorimetric method using TMB. The recombinant CTX-M 2; M14; and M15 protein produced by E. coli was used for analysis.
Fig. 3: Western blot analysis of recombinant CTX-M subtypes with anti-CTX-M (C11) rabbit mAb at 0.1 ug/mL (Cat. 12-4349). HRP-conjugated goat anti rabbit antibody was used as the secondary antibody. Cross-reactivity of the antibody was confirmed by the colorimetric method using TMB. The recombinant CTX-M 2; M14; and M15 protein produced by E. coli was used for analysis.