Phospho-Jak2 (Tyr1007/1008) (Clone: PB6) rabbit mAb
Product Sizes
20 µl
£631.00
12-4343-20UL
200 µl
£1021.00
12-4343-200UL
About this Product
- SKU:
- 12-4343
- Additional Names:
- Tyrosine-protein kinase JAK2; Janus kinase 2; JAK-2
- translate.label.attr.clone:
- Jak2Y10071008-PB6
- Clonality:
- Monoclonal
- Conjugate:
- Unconjugated
- Extra Details:
- Janus kinases (JAKs) are known as non-receptor protein tyrosine kinases. They serve as the catalytic signaling components for a wide range of cytokine receptors; including the receptors for prolactin; interferons; interleukins 3;5 and 6; granulocyte-macrophage colony-stimulating factor (GM-CSF); erythropoietin; thrombopoietin (TPO); leptin; and growth hormone (1). JAKs comprise four intercellular proteins: JAK1-3 and TYK2 (tyrosine kinase-2). They are constitutively associated with the proximal intracellular membrane region of cytokine receptors. In general; binding of cytokines to the extracellular region of their cognate receptors induces conformational changes leading to phosphorylation of JAKs through reciprocal interaction of two juxtapositional JAKs. Hence; JAK activation requires two JAK isoforms either as homodimers or heterodimers to auto-phosphorylate. Consequently; several different combinations of JAKs are associated with different cytokine receptors to recruit and phosphorylate other signaling molecules including members of STAT family (STAT1; STAT2; STAT3; STAT4; STAT5 or STAT6) of DNA binding proteins (2). Specific cytokine receptors belonging to a subclass that includes erythropoietin receptor (EpoR) and growth hormone receptor (GHR) are homodimeric and bind JAK2 exclusively. Once activated; JAKs phosphorylate specific tyrosine residues on the cytokine receptors and subsequently on signal transducer and activator of transcription (STAT) proteins (3); which are recruited to the phosphorylated receptors through their SH2 (Src-homology 2) domains. STATs are transcription factor and after phosphorylation; they translocate to the nucleus to initiate specific transcriptional programs. JAK-STAT signaling pathways are critical for organismal development and homeostasis; particularly in immunity (3).
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- A synthetic phospho-peptide corresponding to residues surrounding Tyr1007/Tyr1008 of human phospho Jak2
- Isotype:
- Rabbit IgG1k
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
