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Antibodies

Phospho-MARCKS (Ser167/170) (Clone: C9) rabbit mAb

Product Sizes
20 µl
£631.00
12-4338-20UL
200 µl
£1021.00
12-4338-200UL
About this Product
SKU:
12-4338
Additional Names:
Myristoylated alanine-rich C-kinase substrate; Protein kinase C substrate; PKCSL; 80 kDa protein light chain; MACS; PRKCSL
translate.label.attr.clone:
MARCKSS167170-C9
Clonality:
Monoclonal
Conjugate:
Unconjugated
Extra Details:
MARCKS (myristoylated alanine-rich C kinase substrate) is a major PKC substrate expressed in all eukaryotic cells(1;2). It binds to and cross-links actin filaments to serve as a bridge between Ca2+/calmodulin and PKC signaling and attenuates phosphatidylinositol 4;5-bisphosphate plasma membrane signaling (3). MARCKS is involved with cell mobility; phagocytosis; membrane traffic; cell adhesion; and mitogenesis. Ser159; 163; 167 and 170 of MARCKS are phosphorylated by PKC in response to cell groeth and cellular stress (4). MARCKs phosphorylation is believe to induce its tranlocation from plasma membrane to cytoplasm.
Format:
Purified
Host:
Rabbit
Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding Ser167/170 of human phospho MARCKS
Isotype:
Rabbit IgG1k
Reactivities:
Human, Mouse, Rat
Shipping Conditions:
Blue Ice
Storage Conditions:
Store at -20[o]C. Avoid repeated freeze and thaw cycles.
Supplier:
Abeomics
Type:
Antibodies:Monoclonal Antibody
  • Manufacturer's Data Sheet:1.jpg
Fig 2 : Flow cytometric analysis of C6 cells; secondary antibody only negative control (blue) or treated with staurosporine (red) or with UV+TPA (green) using Phospho-MARCKS (Ser167/170) antibody MARCKSS167170-C9 at 0.01 µg/mL.
Fig-3: Flow cytometric analysis of 293T cells; secondary antibody only negative control (blue) or untreated (red) or treated with UV+TPA (green) using Phospho-MARCKS (Ser167/170) antibody MARCKSS167170-C9 at 0.01 µg/mL.
Fig-4: Flow cytometric analysis of 293T cells secondary antibody only negative control (blue) or untreated (red) or treated with UV+TPA (green) using 0.1 µg/mL of Phospho-MARCKS (Ser167/170) antibody MARCKSS167170-C9 at 0.01 µg/mL or Company C antibody at 0.5 µg/mL (manufacturer's recommended concentration).
Fig-4: Flow cytometric analysis of 293T cells secondary antibody only negative control (blue) or untreated (red) or treated with UV+TPA (green) using 0.1 µg/mL of Phospho-MARCKS (Ser167/170) antibody MARCKSS167170-C9 at 0.01 µg/mL or Company C antibody at 0.5 µg/mL (manufacturer's recommended concentration).