Skip to content

Basket

You currently have no items in your basket.

Total (excl. vat) £0.00
View basket & checkout
Antibodies

Phospho-Lamin A/C (Ser22) (Clone: CF12) rabbit mAb

Product Sizes
20 µl
£631.00
12-4333-20UL
200 µl
£1021.00
12-4333-200UL
About this Product
SKU:
12-4333
Additional Names:
Prelamin-A/C; 70 kDa lamin; Renal carcinoma antigen NY-REN-32; LMNA; LMN1
translate.label.attr.clone:
LaminACS22-CF12
Clonality:
Monoclonal
Conjugate:
Unconjugated
Extra Details:
Lamins are nuclear membrane proteins that are involved with cell cycle control; chromatin organization; and DNA replication (1;2). Upon caspase 6 cleavage; lamin A/C serves as a molecular marker for capspase 6 activity. Lamin A/C is cleaved during cellular apoptosis into a large (41-50 kDa) as well as a small (28 kDa) fragment leading to nuclear dysfunction and cell death (3) Phosphorylation of lamin A/C at Ser32 by MAPK/CDK signals cell cycle progression and mitosis (4;5).
Format:
Purified
Host:
Rabbit
Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding Ser22 of human phospho Lamin A/C
Isotype:
Rabbit IgG1k
Reactivities:
Human, Mouse
Shipping Conditions:
Blue Ice
Storage Conditions:
Store at -20[o]C. Avoid repeated freeze and thaw cycles.
Supplier:
Abeomics
Type:
Antibodies:Monoclonal Antibody
  • Manufacturer's Data Sheet:1.jpg
Fig 2 : Western blot analysis of HeLa cell extract untreated or treated with nocodazole using Phospho-Lamin A/C (Ser22) antibody LaminACS22-CF12 at 10 ng/mL.
Fig-3: Flow cytometric analysis of NIH 3T3 cells; secondary antibody only negative control (blue); or untreated (red) or treated with nocodazole (green) using Phospho-Lamin A/C (Ser22) antibody LaminACS22-CF12 at 0.05 µg/mL.
Fig-3: Flow cytometric analysis of NIH 3T3 cells; secondary antibody only negative control (blue); or untreated (red) or treated with nocodazole (green) using Phospho-Lamin A/C (Ser22) antibody LaminACS22-CF12 at 0.05 µg/mL.