Phospho-Lyn (Tyr507) (Clone: 5B6) rabbit mAb APC conjugate
Product Sizes
10 Tests
£532.00
12-4327-10TESTS
100 Tests
£792.00
12-4327-100TESTS
About this Product
- SKU:
- 12-4327
- Additional Names:
- Tyrosine-protein kinase Lyn; Lck/Yes-related novel protein tyrosine kinase; V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; p53Lyn; p56Lyn; JTK8
- translate.label.attr.clone:
- LynY507-5B6
- Clonality:
- Monoclonal
- Conjugate:
- APC
- Extra Details:
- Lyn; along with Btk; supports the abnormal growth and survival of neoplastic mast cells. Phosphorylated Lyn has been identified in these cancerous cells; along with phosphorylated Btk; Hck; and Stat5. Dasatinib; a chemotherapy drug used to treat leukemia; is a tyrosine kinase inihibitor that binds directly to Lyn in neoplastic cells. Lyn and Btk have also been shown to be involved in IgE receptor-dependent activation. Increased Lyn activity; detected by higher amounts of phospho Lyn; has been demonstrated in breast cancer cell lines. This is likely mediated through effects of upstream regulators of Lyn; rather than mutations in Lyn itself.
- Format:
- Conjugated
- Host:
- Rabbit
- Immunogen:
- A synthetic phospho-peptide corresponding to residues surrounding Tyr507 of human phospho Lyn
- Isotype:
- Rabbit IgG1k
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
