Phospho-Jak1 (Tyr1022/1023) (Clone: F11) rabbit mAb APC Conjugate
Product Sizes
10 Tests
£532.00
12-4323-10TESTS
100 Tests
£792.00
12-4323-100TESTS
About this Product
- SKU:
- 12-4323
- Additional Names:
- Tyrosine-protein kinase JAK1; Janus kinase 1
- translate.label.attr.clone:
- Jak1Y10221023-F11
- Clonality:
- Monoclonal
- Conjugate:
- APC
- Extra Details:
- Jak1 plays an essential role in the IFN- alpha and IFN-g response pathways and is tyrosine-phosphorylated upon cellular exposure to these signals. Jak1 oral inhibitors have been used to benefit patients with advanced myelofibrosis; where Jak1 was initially shown to be constitutively active in the peripheral blood cells of these patients. Targeted; small-molecule Jak inhibitors have also been used for treatment of rheumatoid arthritis. In cases of advanced melanoma; acquired resistance to PD-1 blockade drugs is associated with loss-of-functions of mutations in Jak1/2 genes. These mutations block interferon gamma signaling and prevent programmed death ligand 1 (PD-L1) expression in tumor cells.
- Format:
- Conjugated
- Host:
- Rabbit
- Immunogen:
- A synthetic phospho-peptide corresponding to residues surrounding Tyr1022/1023 of human phospho-Jak1
- Isotype:
- Rabbit IgG1k
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
