Phospho-HS1 (Tyr397) (Clone: F12) rabbit mAb FITC Conjugate
Product Sizes
10 Tests
£532.00
12-4313-10TESTS
100 Tests
£792.00
12-4313-100TESTS
About this Product
- SKU:
- 12-4313
- Additional Names:
- Hematopoietic lineage cell-specific protein; Hematopoietic cell-specific LYN substrate 1; LckBP1; p75; HCLS1
- translate.label.attr.clone:
- HS1Y397-F12
- Clonality:
- Monoclonal
- Conjugate:
- FITC
- Extra Details:
- HS1 is expressed in lymphoid and hematopoietic cells; and is heavily post-translationally modified. HS1 deficient mouse models have demonstrated the protein's role in receptor-mediated apoptosis and proliferation. HS1 is phosphorylated at Tyr378 and Tyr397 by the kinase Syk; providing a high-affinity binding site for SH2 domains from the Src family. Following this interaction; HS1 is then phosphorylated at Tyr222 by c-Fgr; Lyn; and Fyn kinases. HS1 plays an important role in T cell signaling; where HS1 phosphorylation recruits and activates Vav1 at the immune synapse. As a homolog of the actin binding protein cortactin; HS1 has been shown to mediate neutrophil chemotaxis through phosphorylation of tyrosines 222; 378; and 397.
- Format:
- Conjugated
- Host:
- Rabbit
- Immunogen:
- A synthetic phospho-peptide corresponding to residues surrounding Tyr397 of human phospho HS1
- Isotype:
- Rabbit IgG1k
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
