Phospho-NFKB p65 (Ser536) (Clone: B7) rabbit mAb
Product Sizes
20 µl
£631.00
12-4307-20UL
200 µl
£1021.00
12-4307-200UL
About this Product
- SKU:
- 12-4307
- Additional Names:
- Transcription factor p65; Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; RELA; NFKB3
- translate.label.attr.clone:
- NFKBp65S536-B7
- Clonality:
- Monoclonal
- Conjugate:
- Unconjugated
- Extra Details:
- The nuclear factor kB (NFkB)/Rel family of transcription factors play a pivotal role in inflammatory and immune responses (1;2). NF-kappa-B is present in almost all cell types and is involved in many biological processes including immunity; inflammation; cell growth and differentiation; apoptosis; and tumorigenesis. NFkB is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65; RELB; NFkB1/p105; NFkB1/p50; REL and NFkB2/p52. The dimers bind at kB sites in the target gene DNA. Individual dimers have distinct preferences for different kB sites and can act as either transcriptional activators or repressors. NFkB Ser536 phosphorylation stimulates Lys310 acetylation and interaction of phospho NFkB with CBP. Acetylated/phospho NFkB induces enhanced transcriptional activity.
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- A synthetic phospho-peptide corresponding to residues surrounding Ser536 of human phospho-NFKB p65
- Isotype:
- Rabbit IgG1k
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
