Phospho-S6-Ribosomal Protein (Ser240/244) (Clone: CD10) rabbit mAb APC Conjugate
Product Sizes
10 Tests
£532.00
12-4294-10TESTS
100 Tests
£792.00
12-4294-100TESTS
About this Product
- SKU:
- 12-4294
- Additional Names:
- 40S ribosomal protein S6; Phosphoprotein NP33; Small ribosomal subunit protein eS6; RPS6
- translate.label.attr.clone:
- S6RPS240244-CD10
- Clonality:
- Monoclonal
- Conjugate:
- APC
- Extra Details:
- Ribosomal protein S6 kinase is one of two parallel signaling pathways downstream of mTOR; with the other being 4E-BP1. mTOR phosphorylates and activates S6 kinase; which then phosphorylates ribosomal protein S6. The pathway regulates cell growth and cell cycle progression. The identified phosphorylation sites of S6 are Ser235; Ser236; Ser240; Ser244; and Ser247; which are evolutionarily conserved in higher eukaryotes. Ser236 has been proposed as the primary phosphorylation site. Studies using S6 knockin mice; where all five phosphorylation site serine residues are replaced by alanine; have provided extensive detail on S6 function. These studies support the role phosphorylated S6 plays in regulation of cell size; glucose homeostasis; and protein synthesis.
- Format:
- Conjugated
- Host:
- Rabbit
- Immunogen:
- A synthetic phospho-peptide corresponding to residues surrounding Ser240/244 of human phospho S6 Ribosomal protein
- Isotype:
- Rabbit IgG1k
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
