Phospho-SAPK/JNK (Thr183/Tyr185) (Clone: A11) rabbit mAb APC conjugate
Product Sizes
10 Tests
£532.00
12-4288-10TESTS
100 Tests
£792.00
12-4288-100TESTS
About this Product
- SKU:
- 12-4288
- Additional Names:
- Mitogen-activated protein kinase 8; MAPK8; Stress-activated protein kinase 1c; SAPK1c; c-Jun N-terminal kinase 1; JNK1; PRKM8
- translate.label.attr.clone:
- SAPKT183Y185-A11
- Clonality:
- Monoclonal
- Conjugate:
- APC
- Extra Details:
- The SAPK/JNK pathway initiates apoptosis upon exposure to radiation; UV exposure; heat shock; oxidative stress; and other stressors. Upon exposure to environmental stress; the SAPK/JNK signaling pathway sequentially activates the proteins MEKK1; SEK1; SAPK; and c-Jun. Upstream activators of the SAPK/JNK cascade include ceramide; small GTP-binding proteins such as Rac1 and Cdc42Hs; Ask1; and caspases. MKK7 is also a major and direct SAPK/JNK activator in the TNF alpha or environmental stress signaling pathways; where its kinase activity directly phosphorylates SAPK/JNK. This relationship between MKK7 and SAPK appears to be evolutionarily conserved; as it is preserved in their Drosophila homologues; Hep and DJNK; respectively.
- Format:
- Conjugated
- Host:
- Rabbit
- Immunogen:
- A synthetic phospho-peptide corresponding to residues surrounding Thr183/Tyr185 of human phospho SAPK/JNK
- Isotype:
- Rabbit IgG1k
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
