Phospho-Shp1 (Tyr536) (Clone: 2A7) rabbit mAb PE conjugate
Product Sizes
10 Tests
£532.00
12-4282-10TESTS
100 Tests
£792.00
12-4282-100TESTS
About this Product
- SKU:
- 12-4282
- Additional Names:
- Tyrosine-protein phosphatase non-receptor type 6; Hematopoietic cell protein-tyrosine phosphatase; Protein-tyrosine phosphatase 1C; PTP-1C; SH-PTP1; PTPN6; HCP; PTP1C
- translate.label.attr.clone:
- Shp1Y536-2A7
- Clonality:
- Monoclonal
- Conjugate:
- PE
- Extra Details:
- Src homology-2 domain containing phosphatase-1 (Shp1) typically functions as a negative regulator for signal transduction; interacting with Zap70; CD5; CD3Å’µ; and IL-2R in T cells. Shp1 suppresses cellular signaling by dephosphorylating target proteins. Shp1 is expressed predominantly in hematopoietic cells; where it can plays a role in malignant transformation into cancer cells. Methylation of the Shp1 promoter has been shown to silence Shp1 expression and promote the development of cancer. Shp1 negatively regulates PDGF and insulin tyrosine receptor pathways; and negatively regulates Lck in the TCR signaling pathway to limit TCR responsiveness. Shp1 activity is prevented by TAOK3 in T cells to allow for T cell activation and differentiation.
- Format:
- Conjugated
- Host:
- Rabbit
- Immunogen:
- A synthetic phospho-peptide corresponding to residues surrounding Tyr536 of human phospho Shp1
- Isotype:
- Rabbit IgG1k
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
