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Antibodies

Phospho-PLK1 (Thr210) (Clone: C2) rabbit mAb

Product Sizes
20 µl
£631.00
12-4277-20UL
200 µl
£1021.00
12-4277-200UL
About this Product
SKU:
12-4277
Additional Names:
Serine/threonine-protein kinase PLK1; Polo-like kinase 1; Serine/threonine-protein kinase 13; STPK13
translate.label.attr.clone:
PLK1T210-C2
Clonality:
Monoclonal
Conjugate:
Unconjugated
Extra Details:
PLK1 is activated by phosphorylation of Thr210 in its activation loop. When dephosphorylated; PLK1 auto-inhibition occurs when the Polo-box domain (PDB) binds (and thus inhibits) the kinase domain. PLK1 phosphorylation is directly linked to the cell cycle; as phosphorylation occurs during mitosis but not during interphase. PLK1 is required for successful progression through the mitotic phase. Aurora A phosphorylates PLK1; with the G2-induced Bora protein directly interacting with PLK1 to relieve auto-inhibition. Small-molecule PLK1 inhibitors have played an important role in elucidating PLK1's activities in the cell and have demonstrated the potential of PLK1 as an anti-cancer target. PLK1 inhibition is an efficient cell killer.
Format:
Purified
Host:
Rabbit
Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding Thr210 of human phospho PLK1
Isotype:
Rabbit IgG1k
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
Store at -20[o]C. Avoid repeated freeze and thaw cycles.
Supplier:
Abeomics
Type:
Antibodies:Monoclonal Antibody
  • Manufacturer's Data Sheet:1.jpg
Fig 2 : Peptide blocking flow cytometric analysis of HeLa cells secondary antibody only negative control (light blue) or untreated (red) or treated with nocodazole (green) or untreated and blocked with phospho peptide (black) or treated and blocked with phospho peptide (gold) or untreated and blocked with non-phospho peptide (dark blue) or treated and blocked with non-phospho peptide (purple) using Phospho-PLK1 (Thr210) antibody PLK1T210-C2 at 0.01 µg/mL.
Fig 2 : Peptide blocking flow cytometric analysis of HeLa cells secondary antibody only negative control (light blue) or untreated (red) or treated with nocodazole (green) or untreated and blocked with phospho peptide (black) or treated and blocked with phospho peptide (gold) or untreated and blocked with non-phospho peptide (dark blue) or treated and blocked with non-phospho peptide (purple) using Phospho-PLK1 (Thr210) antibody PLK1T210-C2 at 0.01 µg/mL.