Phospho-Btk (Tyr551) (Clone: G12) rabbit mAb SureLight488 conjugate
Product Sizes
10 Tests
£532.00
12-4276-10TESTS
100 Tests
£792.00
12-4276-100TESTS
About this Product
- SKU:
- 12-4276
- Additional Names:
- Bruton tyrosine kinase; Tyrosine-protein kinase BTK; Agammaglobulinemia tyrosine kinase; ATK; AGMX1; B-cell progenitor kinase; BPK
- translate.label.attr.clone:
- BtkY551-G12
- Clonality:
- Monoclonal
- Conjugate:
- SureLight 488
- Extra Details:
- Btk is a major node in the B-cell receptor signaling pathway; where it regulates B cell maturation; activation; survival; differentiation; and proliferation. Btk is activated by Src family kinases; including Lyn; which phosphorylates Btk at Tyr551. Upon phosphorylation at this site; Btk is recruited to the plasma membrane where autophosphorylation at Tyr223 occurs. The Btk signaling pathway is a major target of small molecule inhibitors for B-cell lymphoma; autoimmune diseases; and non-Hodgkin's lymphomas. These inhibitors either form a covalent bond at Cys481 in the ATP-binding site or serve as reversible inhibitors that bind the SH3 pocket and stabilize inactive Btk.
- Format:
- Conjugated
- Host:
- Rabbit
- Immunogen:
- A synthetic phosphor-peptide corresponding to residues surrounding Tyr551 of human phospho Btk
- Isotype:
- Rabbit IgG1k
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
