Phospho-PKCa (Thr497) (Clone: F1) rabbit mAb PE Conjugate
Product Sizes
10 Tests
£532.00
12-4269-10TESTS
100 Tests
£792.00
12-4269-100TESTS
About this Product
- SKU:
- 12-4269
- Additional Names:
- Protein kinase C alpha type; PKC-alpha; PRKCA; PKCA; PRKACA
- translate.label.attr.clone:
- PKCaT497-F1
- Clonality:
- Monoclonal
- Conjugate:
- PE
- Extra Details:
- PKC alpha is a calcium-dependent isozyme of the PKC family that phosphorylates serine/threonine residues in apoptosis and cellular proliferation and differentiation pathways; including the MAPK cascade. PKC alpha directly phosphorylated Raf-1; inducing survival genes. An increase in PKC alpha is associated with multi-drug resistance in cancer cell lines; and increased expression in breast cancers is noted as causing a particularly malignant phenotype. Thus PKC alpha has been the target of novel cancer therapeutics; with some promising developments in microRNA inhibitors. PKC alpha is itself phosphorylated by mTOR. PKC alpha also plays an important role in water regulator and solute absorption in the cell; where it regulates aquaporin 2 by initiating AQP2 ubiquination and lysosomal degradation.
- Format:
- Conjugated
- Host:
- Rabbit
- Immunogen:
- A synthetic phospho-peptide corresponding to residues surrounding Thr497 of human phospho PKC alpha
- Isotype:
- Rabbit IgG1k
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
