Phospho-Stat5 (Tyr694) (Clone: G11) rabbit mAb PE conjugate
Product Sizes
10 Tests
£532.00
12-4261-10TESTS
100 Tests
£792.00
12-4261-100TESTS
About this Product
- SKU:
- 12-4261
- Additional Names:
- Signal transducer and activator of transcription 5A; STAT5A; Signal transducer and activator of transcription 5B; STAT5B
- translate.label.attr.clone:
- Stat5Y694-G11
- Clonality:
- Monoclonal
- Conjugate:
- PE
- Extra Details:
- Stat5 activation occurs in response to many ligands including prolactin; IL-2; growth hormone; and GM-CSF. Tyr694 phosphorylation is obligatory activation of Stat5 (1;2); and is mediated by Src upon erythropoietin stimulation (3). Phospho Stat5 is constitutively active in some leukemic cell types (4); and phospho Stat5 is found in some endothelial cells when treated with IL-3; suggesting its involvement in cell motility and angiogenesis (5). Stat5 has been shown to be encoded by two separate genes; Stat5a and Stat5b; which share over 90% amino acid sequence identity. In different cell types; Stat5a and Stat5b are independently regulated and activated. For example; interferon treatment predominantly activates Stat5a in U937 cells and Stat5b in HeLa cells (6).
- Format:
- Conjugated
- Host:
- Rabbit
- Immunogen:
- A synthetic phospho-peptide corresponding to residues surrounding Tyr695 of human phospho Stat5
- Isotype:
- Rabbit IgG1k
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
