Phospho-c-Cbl (Tyr774) (Clone: R3B8) rabbit mAb FITC conjugate
Product Sizes
10 Tests
£532.00
12-4252-10TESTS
100 Tests
£792.00
12-4252-100TESTS
About this Product
- SKU:
- 12-4252
- Additional Names:
- E3 ubiquitin-protein ligase CBL; Casitas B-lineage lymphoma proto-oncogene; Proto-oncogene c-Cbl; RING finger protein 55; RING-type E3 ubiquitin transferase; Signal transduction protein CBL; CBL2; RNF55
- translate.label.attr.clone:
- CblY774-R3B8
- Clonality:
- Monoclonal
- Conjugate:
- FITC
- Extra Details:
- The c-Cbl (Casitas B-lineage Lymphoma) proto-oncogene is a ubiquitously expressed cytoplasmic adaptor protein that contains multiple functional domains; including an amino-terminal tyrosine kinase-binding (TKB) domain; a RING finger motif; and a proline-rich region. The TKB recognizes phosphorylated tyrosines on activated receptor tyrosine kinases (RTKs) and on other nonreceptor tyrosine kinases; while the RING finger motif recruits ubiquitin-conjugating enzymes. These two domains are primarily responsible for the ubiquitin ligase activity of c-Cbl and downregulation of RTKs (1). The proline-rich region contains 14-3-3 protein-binding and SH3 domain-binding motifs. c-Cbl is phosphorylated at Y700; Y731; and Y774 by Syk- and Src-family kinases after the stimulation of some integrins and a wide variety of receptors for immunoglobulins; antigens; hormones; growth factors; and cytokines. Phosphorylated Y774 interacts with the SH2 domain of Crk (1;2). The c-Cbl adapter protein is expressed in the cytoplasm in all tissues; with especially high levels of expression in hematopoietic cells (3;4). Through its many functional sites; c-Cbl plays key roles in the positive and negative regulation of vital cell functions; including T Cell Receptor-mediated cellular immune responses. In human cancer tissues; c-Cbl is frequently tyrosine-phosphorylated in a tumor-specific manner (5).
- Format:
- Conjugated
- Host:
- Rabbit
- Immunogen:
- A synthetic phospho-peptide corresponding to residues surrounding Tyr774 of human phospho c-Cbl
- Isotype:
- Rabbit IgG1k
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
