Phospho-Lck (Tyr505) (Clone: A3) rabbit mAb SureLight488 conjugate
Product Sizes
10 Tests
£532.00
12-4246-10TESTS
100 Tests
£792.00
12-4246-100TESTS
About this Product
- SKU:
- 12-4246
- Additional Names:
- Tyrosine-protein kinase Lck; Leukocyte C-terminal Src kinase; LSK; Protein YT16; T cell-specific protein-tyrosine kinase
- translate.label.attr.clone:
- LckY505-A3
- Clonality:
- Monoclonal
- Conjugate:
- SureLight 488
- Extra Details:
- Lck is a member of the Src family of non-receptor tyrosine kinases and plays a major role in T cell activation. Lck activates many downstream signaling pathways including Akt/mTOR; SAPK/JNK; PLCg1; and RAS/MAPK. Phosphorylation of Lck at Tyr394 in the catalytic domain at the ATP-binding site stabilizes the open and active form; while phosphorylation at Tyr505 in the C-terminal domain promotes the closed; inactive conformation. Multiple small-molecule drugs used to treat leukemia have been shown to target inhibition of Lck; including imatinib and dasatinib. Lck is thus a promising target for suppressing T-cell responses for the treatment of inflammatory diseases or after organ transplantation.
- Format:
- Conjugated
- Host:
- Rabbit
- Immunogen:
- A synthetic phospho-peptide corresponding to residues surrounding Tyr505 of human phospho Lck
- Isotype:
- Rabbit IgG1k
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
