Phospho-Stat4 (Tyr693) (Clone: F6) rabbit mAb SureLight488 conjugate
Product Sizes
10 Tests
£532.00
12-4235-10TESTS
100 Tests
£792.00
12-4235-100TESTS
About this Product
- SKU:
- 12-4235
- Additional Names:
- Signal transducer and activator of transcription 4
- translate.label.attr.clone:
- Stat4Y693-F6
- Clonality:
- Monoclonal
- Conjugate:
- SureLight 488
- Extra Details:
- In response to IL-12 binding; the IL-12 receptor activates the Jak kinases; which phosphorylate tyrosine residues of IL-12RB2. These phosphorylated receptors recruit Stat4 through its SH2 domain; whereupon Stat4 is phosphorylated at Tyr693 in its C-terminal transactivation domain. Phosphorylation promotes Stat4 homodimerization and translocation to the nucleus; where it promotes gene transcription. The N-terminal domain of Stat4 appears to be required for maximal stabilization and for the binding of Stat4 dimers to lower-affinity DNA binding sites. Stat4-deficient mice have demonstrated that this gene is required to both promote Th1 development and inhibit Th2 differentiation due to disabling IL-12 receptor-mediated responses.
- Format:
- Conjugated
- Host:
- Rabbit
- Immunogen:
- A synthetic phospho-peptide corresponding to residues surrounding Tyr693 of human phospho-Stat4
- Isotype:
- Rabbit IgG1k
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
