Phospho-SLP-76 (Tyr128) (Clone: 3F8) rabbit mAb SureLight488 conjugate
Product Sizes
10 Tests
£532.00
12-4182-10TESTS
100 Tests
£792.00
12-4182-100TESTS
About this Product
- SKU:
- 12-4182
- Additional Names:
- Lymphocyte cytosolic protein 2; SH2 domain-containing leukocyte protein of 76 kDa; SLP76; LCP2
- translate.label.attr.clone:
- SLP76Y128-3F8
- Clonality:
- Monoclonal
- Conjugate:
- SureLight 488
- Extra Details:
- SH2 Domain-Containing Leukocyte Protein Of 76 KDa (SLP-76) is an adaptor protein that plays a role in signal transduction in T cells. Studies using a SLP-76-deficient T cell line have demonstrated that SLP-76 is required for optimal phosphorylation and activation of both PLCg1 and the Ras pathway. SLP-76 phosphorylation is mediated by Zap70 upon TCR stimulation. Within an N-terminal acidic region; SLP-76 possesses three tyrosines (Tyr113; 128; and 145); which are phosphorylated upon activation. The sterile alpha-motif (SAM) domain of SLP-76 drives formation of dimers and higher order oligomers. SLP-76 micro-clusters at the immunological synapse enhance signal transduction and T cell activation.
- Format:
- Conjugated
- Host:
- Rabbit
- Immunogen:
- A synthetic phospho-peptide corresponding to residues surrounding Tyr128 of human phospho SLP-76
- Isotype:
- Rabbit IgG1k
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
