Phospho-CrkL (Tyr207) (Clone: G4) rabbit mAb APC conjugate
Product Sizes
10 Tests
£532.00
12-4161-10TESTS
100 Tests
£792.00
12-4161-100TESTS
About this Product
- SKU:
- 12-4161
- Additional Names:
- Crk-like protein; CRKL; v-crk sarcoma virus CT10 oncogene homolog (avian)-like
- translate.label.attr.clone:
- CrkLY207-G4
- Clonality:
- Monoclonal
- Conjugate:
- APC
- Extra Details:
- CrkL (v-Crk sarcoma virus CT10 oncogene-like protein) is an adaptor protein composed of one Src Homology 2 (SH2) and two Src Homology 3 (SH3) domains separated by flexible linker sequences that act as building blocks to assemble multiprotein complexes (1). The Crk adaptor proteins (Crk and CrkL) constitute an integral part of a network of essential signal transduction pathways in humans and other organisms that act as major convergence points in tyrosine kinase signaling. CRKL is required for the normal development of multiple tissues that rely on fibroblast growth factor 8 (FGF8). Phosphorylation of Crk on Tyr 221 or CrkL on Tyr 207 causes intramolecular binding of the linker region to the SH2 domain; sequestering the SH2 and SH3N and preventing them from binding target proteins (2;3). Mounting evidence indicates that dysregulation of Crk proteins is associated with human diseases; including cancer and susceptibility to pathogen infections.
- Format:
- Conjugated
- Host:
- Rabbit
- Immunogen:
- A synthetic phospho-peptide corresponding to residues surrounding Tyr207 of human phospho CrkL
- Isotype:
- Rabbit IgG1k
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
