Phospho-Stat1 (Ser727) (Clone: C6) rabbit mAb PE conjugate
Product Sizes
10 Tests
£532.00
12-4128-10TESTS
100 Tests
£792.00
12-4128-100TESTS
About this Product
- SKU:
- 12-4128
- Additional Names:
- Signal transducer and activator of transcription 1-alpha/beta; Transcription factor ISGF-3 components p91/p84
- translate.label.attr.clone:
- Stat1S727-C6
- Clonality:
- Monoclonal
- Conjugate:
- PE
- Extra Details:
- Stat1 mediates the cellular response to IFN alpha; IFNB; and IFNg for the regulation of cell growth and the defense against viral and immune challenges. The Jak-Stat pathway plays a central role in the IFNg response; where Stat1 phosphorylation on Tyr701 causes homodimerization through its SH2 domain; translocation to the nucleus; and binding to gamma-activated sequence (GAS) elements. Early in the activation sequence; Stat1 is also phosphorylated at Ser727 through a mechanism involving PI3 kinase and Akt. Stat1 has been found to correlate with increased resistance to chemotherapeutic drugs. However; Stat1 activation of the immune system helps suppress tumor growth; and multiple melanomas and squamous-cell carcinomas have been known to downregulate Stat1 expression to evade immune surveillance.
- Format:
- Conjugated
- Host:
- Rabbit
- Immunogen:
- A synthetic phospho-peptide corresponding to residues surrounding Ser727 of human phospho Stat1
- Isotype:
- Rabbit IgG1k
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
