Phospho-MET (Tyr1234/1235) (Clone: 6F11) rabbit mAb
Product Sizes
20 µl
£631.00
12-4101-20UL
200 µl
£1021.00
12-4101-200UL
About this Product
- SKU:
- 12-4101
- Additional Names:
- AUTS9; c-Met; Hepatocyte growth factor receptor; HGF receptor; HGF/SF receptor; HGFR; MET; met proto-oncogene (hepatocyte growth factor receptor); met proto-oncogene tyrosine kinase; oncogene MET; Proto-oncogene c-Met; RCCP2; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met
- translate.label.attr.clone:
- MetY12341235-6F11
- Clonality:
- Monoclonal
- Conjugate:
- Unconjugated
- Extra Details:
- c-Met; also called tyrosine-protein kinase MET or hepatocyte growth factor receptor (HGFR); has tyrosine kinase activity (1). MET is a single pass tyrosine kinase receptor essential for embryonic development; organogenesis and wound healing. Normally; MET is expressed only in stems cells and progenitor cells but excessive expression of MET/HGFR and its autocrine activation by co-expression of hepatocyte growth factor (HGF) ligand are implicated in oncogenesis (2;3). Aberrantly activated MET leads to tumor growth; angiogenesis; and cancer metastasis and is correlated with poor prognosis. Abnormal activation of MET is observed in various human malignancies; such as kidney; liver; stomach; breast; and brain. MET activation by HGF induces MET kinase catalytic activity and leads to phosphorylation at Tyr 1234 and Tyr 1235.
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- A synthetic phospho-peptide corresponding to residues surrounding Tyr1234/Tyr1235 of human phospho Met
- Isotype:
- Rabbit IgG1k
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
