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Antibodies

Phospho-NDRG1 (Thr346) (Clone: F5) rabbit mAb

Product Sizes
20 µl
£631.00
12-4079-20UL
200 µl
£1021.00
12-4079-200UL
About this Product
SKU:
12-4079
Additional Names:
Differentiation-related gene 1 protein; N-myc downstream-regulated gene 1 protein; Nickel-specific induction protein Cap43; Reducing agents and tunicamycin-responsive protein; RTP; Rit42
translate.label.attr.clone:
NDRG1T346-F5
Clonality:
Monoclonal
Conjugate:
Unconjugated
Extra Details:
N-Myc down-regulated gene 1 (NDRG1) has been reported to be a direct transcriptional target of p53. NDRG1 appears to play a necessary; but not sufficient; role in apoptosis; though its exact mechanism of action remains unknown. NDRG1 expression is elevated in non-small cell lung cancer cells; promoting cancer growth and reducing cytotoxicity to certain anti-cancer drugs. NDRG1 is also elevated in solid tumors and is recognized as a negative prognostic indicator in breast cancer. Elevated NDRG1 expression is correlated with disease recurrence and metastasis in breast cancer. NDRG1 is phosphorylated by Sgk1; which itself is activated by mTORC2. Phosphorylation of NDRG1 at Thr346 promotes cellular differentiation in adipocytes.
Format:
Purified
Host:
Rabbit
Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding Thr346 of human phospho NDRG1
Isotype:
Rabbit IgG1k
Reactivities:
Human, Mouse
Shipping Conditions:
Blue Ice
Storage Conditions:
Store at -20[o]C. Avoid repeated freeze and thaw cycles.
Supplier:
Abeomics
Type:
Antibodies:Monoclonal Antibody
  • Manufacturer's Data Sheet:1.jpg
Fig 2 : Peptide blocking flow cytometric analysis of THP1 cells secondary antibody only negative control (light blue) or untreated (orange) using isotype control antibody or untreated (red) or with IFNa + IL-4 + pervanadate (green) or untreated and blocked with phospho-peptide (black) or treated and blocked with phospho peptide (gold) or untreated and blocked with non-phospho peptide (dark blue) or treated and blocked with non-phospho peptide (purple) using Phospho-NDRG1 (Thr346) antibody NDRG1T
Fig-3: Western blot analysis of C2C12 cell extract untreated or treated with LY294002 using 0.05 µg/mL Phospho-NDRG1 (Thr346) antibody NDRG1T346-F5
Fig-4: Western blot analysis of C2C12 cell extract untreated or treated with LY294002 using 0.05 µg/mL Phospho-NDRG1 (Thr346) antibody NDRG1T346-F5 or Company C antibody at 0.07 µg/mL (manufacturer's recommended concentration) developed using the same exposure.
Fig-4: Western blot analysis of C2C12 cell extract untreated or treated with LY294002 using 0.05 µg/mL Phospho-NDRG1 (Thr346) antibody NDRG1T346-F5 or Company C antibody at 0.07 µg/mL (manufacturer's recommended concentration) developed using the same exposure.