Phospho-Shp2 (Tyr580) (Clone: 4A2) rabbit mAb FITC conjugate
Product Sizes
10 Tests
£532.00
12-4078-10TESTS
100 Tests
£792.00
12-4078-100TESTS
About this Product
- SKU:
- 12-4078
- Additional Names:
- Tyrosine-protein phosphatase non-receptor type 11; Protein-tyrosine phosphatase 1D; PTP-1D; Protein-tyrosine phosphatase 2C; SH-PTP3; PTPN11; PTP2C; SHPTP2
- translate.label.attr.clone:
- Shp2Y580-4A2
- Clonality:
- Monoclonal
- Conjugate:
- FITC
- Extra Details:
- Src homology region 2 (SH2)-containing protein tyrosine phosphatase 2 (Shp2; phospho Shp2); encoded by PTPN11 gene; is a non-receptor phosphotyrosine phosphatase which is ubiquitously expressed in mammalian cells and contain one protein tyrosine phosphatase (PTP) catalytic domain and two SH2 domains. The phosphatase active site is located in the C-terminal of Shp2. Shp2 is phosphorylated by several stimulants and cytokines at Tyr580 inducing Shp2 activation. Activated Shp2 recruits Grb2 and Tyr580 phosphorylation of phospho Shp2 functions as the main binding site of Grb2; thereby activating downstream Ras in response to growth factors. In turn Grb2 controls FGFR2 phosphorylation by inhibiting receptor kinase and Shp2 phosphatase activity. Shp2 also promotes both ERK1/2 and PI3K/AKT signaling. High levels of Shp2 has been found in several cancer types including breast cancer and melanoma.
- Format:
- Conjugated
- Host:
- Rabbit
- Immunogen:
- A synthetic phospho-peptide corresponding to residues surrounding Tyr580 of human phospho Shp2
- Isotype:
- Rabbit IgG1k
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
