Phospho-EGFR (Tyr1068) (Clone: E5) rabbit mAb FITC conjugate
Product Sizes
10 Tests
£532.00
12-4070-10TESTS
100 Tests
£792.00
12-4070-100TESTS
About this Product
- SKU:
- 12-4070
- Additional Names:
- avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; EGFR; Epidermal growth factor receptor; epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog; avian); ERBB; ERBB1; HER1; mE
- translate.label.attr.clone:
- EGFRY1068-E5
- Clonality:
- Monoclonal
- Conjugate:
- FITC
- Extra Details:
- The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands (1). EGFR (rbB-1) is closely related to other members of the ErbB family of receptors: HER2/neu(ErbB-2); HER3 (ErbB-3) and HER4 (ErbB-4). In many cancer types; mutations affecting EGFR expression or activity could result in cancer (2). Overexpression of EGFR is associated with the development of a wide variety of tumors. Interruption of EGFR signaling; either by blocking EGFR binding sites on the extracellular domain of the receptor or by inhibiting intracellular tyrosine kinase activity; can prevent the growth of EGFR-expressing tumors and improve the patient's condition. EGFR is activated by the binding of its ligands including EGF and dimerization stimulates its intrinsic intracellular protein-tyrosine kinase activity. Activation of EGFR leads to autophosphorylation of tyrosine (Tyr) residues; Tyr992; Tyr1045; Y1068; Tyr1148; and Tyr1173 in the C-terminal domain.
- Format:
- Conjugated
- Host:
- Rabbit
- Immunogen:
- A synthetic phospho-peptide corresponding to residues surrounding Tyr1068 of human phospho EGFR.
- Isotype:
- Rabbit IgG1k
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
