Phospho-Histone H3 (Ser10) (Clone: 4B6) rabbit mAb PE conjugate
Product Sizes
10 Tests
£532.00
12-4055-10TESTS
100 Tests
£792.00
12-4055-100TESTS
About this Product
- SKU:
- 12-4055
- Additional Names:
- Histone H3.1t; H3t; H3FT; HIST3H3
- translate.label.attr.clone:
- HisH3S10-4B6
- Clonality:
- Monoclonal
- Conjugate:
- PE
- Extra Details:
- Histones are highly conserved proteins that serve the core of nucleosomes; which serve to organize chromatin fiber for DNA packing. Histone H3 phosphorylation plays a major role in both transcriptional activation; which requires unpacking of the chromatin structure; and in chromosome packing during cell division. Histone H3 is phosphorylated at residues Ser10 and Ser28; and is acetylated at Lys14. Phosphorylation at Ser10 occurs during entry into mitosis prior to chromatin condensation; and phosphorylation at Ser28 follows a similar pattern. In response to EGF stimulation; it has been proposed that sequential Ser10 phosphorylation; then Lys14 acetylation occurs; causing a change in chromatin structure and gene activation.
- Format:
- Conjugated
- Host:
- Rabbit
- Immunogen:
- A synthetic phospho-peptide corresponding to residues surrounding Ser10 of human phospho histone H3
- Isotype:
- Rabbit IgG1k
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
