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Antibodies

Phospho-Histone H3 (Ser10) (Clone: 4B6) rabbit mAb

Product Sizes
200 µl
£1021.00
12-4054-200UL
About this Product
SKU:
12-4054
Additional Names:
Histone H3.1t; H3t; H3FT; HIST3H3
translate.label.attr.clone:
HisH3S10-4B6
Clonality:
Monoclonal
Conjugate:
Unconjugated
Extra Details:
Histones are highly conserved proteins that serve the core of nucleosomes; which serve to organize chromatin fiber for DNA packing. Histone H3 phosphorylation plays a major role in both transcriptional activation; which requires unpacking of the chromatin structure; and in chromosome packing during cell division. Histone H3 is phosphorylated at residues Ser10 and Ser28; and is acetylated at Lys14. Phosphorylation at Ser10 occurs during entry into mitosis prior to chromatin condensation; and phosphorylation at Ser28 follows a similar pattern. In response to EGF stimulation; it has been proposed that sequential Ser10 phosphorylation; then Lys14 acetylation occurs; causing a change in chromatin structure and gene activation.
Format:
Purified
Host:
Rabbit
Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding Ser10 of human phospho histone H3
Isotype:
Rabbit IgG1k
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
Store at -20[o]C. Avoid repeated freeze and thaw cycles.
Supplier:
Abeomics
Type:
Antibodies:Monoclonal Antibody
  • Manufacturer's Data Sheet:1.jpg
Fig 2 : Western blot analysis of Jurkat cell extract untreated or treated with calyculin A using Phospho-Histone H3 (Ser10) antibody HisH3S10-4B6.
Fig-3: Western blot analysis of A549 cell extract untreated or treated with nocodazole using 0.01 µg/mL Phospho-Histone H3 (Ser10) antibody HisH3S10-4B6 or Company C antibody at 0.03 µg/mL (manufacturer's recommended concentration) developed using the same exposure.
Fig-3: Western blot analysis of A549 cell extract untreated or treated with nocodazole using 0.01 µg/mL Phospho-Histone H3 (Ser10) antibody HisH3S10-4B6 or Company C antibody at 0.03 µg/mL (manufacturer's recommended concentration) developed using the same exposure.