Phospho-PLCg2 (Tyr759) (Clone: G3) rabbit mAb APC conjugate
Product Sizes
10 Tests
£532.00
12-4028-10TESTS
100 Tests
£792.00
12-4028-100TESTS
About this Product
- SKU:
- 12-4028
- Additional Names:
- 1-phosphatidylinositol 4;5-bisphosphate phosphodiesterase gamma-2; Phosphoinositide phospholipase C-gamma-2; PLC-IV; PLC-gamma-2; PLCG2
- translate.label.attr.clone:
- PLCG2Y759-G3
- Clonality:
- Monoclonal
- Conjugate:
- APC
- Extra Details:
- The PLC-gamma isoforms of the PI-PLC family of lipases are regulated by growth factor receptors and B- and T-cell antigen receptors. While PLCg1 is expressed ubiquitously; PLCg2 is predominantly expressed in liver cells. PLCg2 plays a dominant role in B-cell signaling. Btk directly phosphorylates PLCg2; though the Syk kinase and BLNK adaptor protein are required. Both Tyr753 and Tyr759 have been identified as important phosphorylation sites for PLCg2 activation in B-cells. PLCg2 missense mutations and genomic deletions have been identified autoinflammatory diseases in humans. These include gain-of-function mutations; such as S707T; that possibly introduce an additional phosphorylation site and increase basal PLCg2 activity.
- Format:
- Conjugated
- Host:
- Rabbit
- Immunogen:
- A synthetic phospho-peptide corresponding to residues surrounding Tyr759 of human phospho PLCg2.
- Isotype:
- Rabbit IgG1k
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
