Human/Mouse Myl9/12 (Clone: F6) rabbit mAb
Product Sizes
100 µg
£856.00
12-4020-100UG
About this Product
- SKU:
- 12-4020
- Additional Names:
- Myosin regulatory light polypeptide 9; 20 kDa myosin light chain; LC20; MLC-2C; Myosin RLC; Myosin regulatory light chain 9; Myosin regulatory light chain MRLC1
- translate.label.attr.clone:
- AWBMyl9F6 (F-6)
- Clonality:
- Monoclonal
- Conjugate:
- Unconjugated
- Extra Details:
- Myosin regulatory light chain (Myl) 9 is a regulatory subunit of the ATPase myosin protein. Myl9 regulates actin rearrangement to direct cellular migration; shape; and adhesion. Myl9 itself is regulated by post-translational modifications; including phosphorylation; acetylation and methylation. Phosphorylation of Myl9 at Thr18 and Ser19 promotes myosin ATPase activity and interaction with actin. N alpha-acetylation of Myl9 has been shown to increase Ser19 phosphorylation and cytoplasmic activity; while N alpha-methylation promotes DNA binding in the nucleus. Myl9; Myl12a; and Myl12b (Myl9/12) have been identified as functional ligands for CD69 in inflamed lungs; playing a major role in chronic inflammatory disorders such as chronic rhinosinusitis. Homozygous deletion in the MYL9 gene in humans has been identified as a putative molecular basis of the disease megacystis-microcolon-intestinal hypoperistalsis (MMIHS) syndrome; especially considering Myl9's role in contracting smooth muscle cell.
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- N-terminal peptide of Myl9
- Isotype:
- Rabbit IgG1k
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
