Anti-Tyrosinase (Melanoma Marker) Recombinant Mouse Monoclonal Antibody (Clone:rOCA1/812)
Product Sizes
20 µg
£408.00
12-1261-20UG
100 µg
£716.00
12-1261-100UG
About this Product
- SKU:
- 12-1261
- Additional Names:
- ATN; CMM8; LB24-AB; Monophenol monooxygenase; OCA1; OCA1A; Oculocutaneous albinism IA; SHEP3; SK29-AB; Tumor rejection antigen AB; TYR
- translate.label.attr.clone:
- rOCA1/812
- Clonality:
- Monoclonal
- Extra Details:
- Recognizes a cluster of proteins between 70-80kDa; identified as tyrosinase. Occasionally a minor band at 55kDa is also detected. This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1; TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3;4-dihydroxy-phenylalanine (dopa); and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants.This MAb is a useful marker for melanocytes and melanomas.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human tyrosinase protein
- Isotype:
- Mouse IgG1; kappa
- Purification:
- Protein A/G
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
