Anti-p53 Tumor Suppressor Protein Recombinant Mouse Monoclonal Antibody (Clone:TP53/1739)
Product Sizes
20 µg
£408.00
12-1232-20UG
100 µg
£716.00
12-1232-100UG
About this Product
- SKU:
- 12-1232
- Additional Names:
- Antigen NY-CO-13; BCC7; Cellular Tumor Antigen p53; LFS1; TP53; Transformation Related Protein 53 (TRP53); Tumor Protein p53; Tumor Suppressor p53
- translate.label.attr.clone:
- TP53/1739
- Clonality:
- Monoclonal
- Extra Details:
- The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array; containing more than 19;000; full-length human proteins. Recognizes a 53kDa protein; which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53. It is a tumor suppressor protein expressed in a wide variety of tissue types and is involved in regulating cell growth; replication; and apoptosis. It binds to MDM2; SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast; lung; colorectal; and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in many malignant tumors; including breast; ovarian; bladder; colon; lung; and melanoma.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human TP53 protein
- Isotype:
- Mouse IgG2a; kappa
- Purification:
- Protein A/G
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
