Anti-Insulin Receptor Alpha Recombinant Rabbit Monoclonal Antibody (Clone:INSR/2277R)
Product Sizes
20 µg
£408.00
12-1200-20UG
100 µg
£716.00
12-1200-100UG
About this Product
- SKU:
- 12-1200
- Additional Names:
- CD220; HHF5; HIR A; INSR; Insulin receptor; Insulin receptor subunit alpha; IR
- translate.label.attr.clone:
- INSR/2277R
- Clonality:
- Monoclonal
- Extra Details:
- The insulin receptor (IR) is a heterodimeric protein complex that has an intracellular and an extracellular subunit; which is disulfide-linked to a transmembrane segment. The insulin ligand binds to the IR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to IR induces phosphorylation of intra-cellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin. Type 1 diabetes is an auto-immune condition of the endocrine pancreas that results in destruction of insulin secreting cells and a progressive loss in insulin-sensitive glucose uptake by cells.
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Recombinant fragment of extracellular domain of human Insulin Receptor alpha (exact sequence is proprietary)
- Isotype:
- Rabbit IgG
- Purification:
- Protein A/G
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
