Polyclonal Antibody to Neurog 3/Ngn 3
Product Sizes
25ug
£319.00
11-8071-25UG
100ug
£407.00
11-8071-100UG
About this Product
- SKU:
- 11-8071
- Additional Names:
- Class A basic helix-loop-helix protein 7; Protein atonal homolog 5; ATOH5; BHLHA7; NGN3
- Clonality:
- Polyclonal
- Extra Details:
- Neurog 3/Ngn 3 belongs to the bHLH (basic helix-loop-helix) class of transcription factors and functions primarily as an activator of gene transcription in endocrine progenitor cells. It is expressed in a small percentage of cells within the developing pancreas consisting of endocrine progenitor cells, and functions to directly enhance the expression of the lineage-committed transcription factors required for the differentiation of the endocrine progenitor cells into each of the endocrine cell subtypes. Ngn3 binds directly to the promoters of the beta -cell specific transcription factors beta2/NeuroD and Pax4 to promote the differentiation of progenitor cells into the b cell lineage. Ngn3 expression is extinguished coincident with the expression of the endocrine hormones that define the endocrine lineages, for example the insulin expression in beta cells. (21099270, 18599526)
- Format:
- Purified
- Gene Details:
- NEUROG3
- Host:
- Rabbit
- Immunogen:
- Full length recombinant Ngn3 protein was used as the immunogen for this antibody.
- Isotype:
- Rabbit IgG
- Purification:
- Protein A Chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
