Polyclonal Antibody to SPARC/Osteonectin
Product Sizes
25ug
£319.00
11-7512-25UG
100ug
£407.00
11-7512-100UG
About this Product
- SKU:
- 11-7512
- Additional Names:
- SPARC||ON
- Clonality:
- Polyclonal
- Extra Details:
- SPARC (Secreted protein, acidic, cysteine-rich) is a glycoprotein that binds to collagen type I and other proteins in the extracellular matrix. It is involved in normal tissue remodeling as it regulates the deposition of extracellular matrix, and also plays a role in neoplastic transformation. It modulates interactions between tumoral cells and the peri-tumoral stroma. Homozygous mutations in SPARC give rise to severe bone fragility in humans. SPARC negatively regulates glucose metabolism in hepatocellular carcinoma (HCC). Overexpression of SPARC inhibited glucose uptake and lactate product through downregulation of key enzymes of glucose metabolism.
- Format:
- Purified
- Gene Details:
- SPARC
- Host:
- Rabbit
- Immunogen:
- A partial length recombinant SPARC/Osteonectin protein (amino acids 52-268) was used as the immunogen for this antibody.
- Isotype:
- Rabbit IgG
- Purification:
- Protein A Chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
