Polyclonal Antibody to ICAD
Product Sizes
25ug
£319.00
11-7002-25UG
100ug
£407.00
11-7002-100UG
About this Product
- SKU:
- 11-7002
- Additional Names:
- DFFA||DFF1||DFF45||H13
- Clonality:
- Polyclonal
- Extra Details:
- ICAD/DFF45 is an inhibitor of the caspase-activated DNase (CAD, DFF40). DNA fragmentation factor (DFF) consists of two subunits, a 40 kDa caspase-activated nuclease (DFF40) and a 45 kDa inhibitor (DFF45). In proliferating cells CAD or DFF40 forms a complex with ICAD or DFF45. When cells undergo apoptosis, caspase 3 cleaves ICAD at two sites to dissociate the CAD:ICAD complex, allowing CAD to cleave chromosomal DNA. Thus DEF induces the fragmentation of DNA which is a hallmark of apoptosis. ICAD is expressed in brain, blood, skin, spleen, adipose tissue. It has 2 isoforms produced by alternative splicing.
- Format:
- Purified
- Gene Details:
- DFFA
- Host:
- Rabbit
- Immunogen:
- A partial length recombinant ICAD protein (amino acids 111-331) was used as the immunogen for this antibody.
- Isotype:
- Rabbit IgG
- Purification:
- Protein A Chromatography
- Reactivities:
- Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
