Mouse Monoclonal Antibody to Insulin Receptor (Clone: IR-1)
Product Sizes
100ug
£429.00
10-7605-100UG
About this Product
- SKU:
- 10-7605
- Additional Names:
- CD220; HHF5; HIR A; INSR; Insulin receptor; Insulin receptor; IR
- translate.label.attr.clone:
- IR-1
- Clonality:
- Monoclonal
- Extra Details:
- The insulin receptor (IR) is a heterodimeric protein complex that has an intracellular subunit and an extracellular subunit, which is disulfide-linked to a transmembrane segment. The insulin ligand binds to the IR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to IR induces phosphorylation of intra-cellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin. Type 1 diabetes is an auto-immune condition of the endocrine pancreas that results in destruction of insulin secreting cells and a progressive loss in insulin-sensitive glucose uptake by cells.
- Format:
- Purified
- Gene Details:
- INSR
- Host:
- Mouse
- Isotype:
- Mouse IgG1, kappa light chain
- Purification:
- Protein G Chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2 to 8[o]C. For long term storage; store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:Insulin R FLOW 10-7605.png
