Monoclonal Antibody to BCL-6 (Clone: ABM44G9)
Product Sizes
25ug
£319.00
10-7557-25UG
100ug
£429.00
10-7557-100UG
About this Product
- SKU:
- 10-7557
- Additional Names:
- BCL6||BCL5||LAZ3||ZBTB27||ZNF51
- translate.label.attr.clone:
- ABM44G9
- Clonality:
- Monoclonal
- Extra Details:
- BCL6 (B-cell lymphoma 6) is a 95 kDa zinc finger transcription factor and contains an N-terminal POZ domain. BCL6 is a transcriptional repressor and a master regulator of the germinal center (GC) B cell phenotype controlling its development and growth. BCL-6 modulates IL-4, BCR, and CD40L signals for normal B cell development. Altered BCL6 protein expression is implicated in pathogenesis of diverse human hematologic malignancies, especially in the diffuse large B cell lymphoma (DLBCL), the most common lymphoma in adults. BCL6 suppresses the expression of p53 (also known as tp53) tumor suppressor gene and modulates DNA damage-induced apoptotic responses in GC B cells.
- Format:
- Purified
- Gene Details:
- BCL6
- Host:
- Mouse
- Immunogen:
- A partial length recombinant BCL-6 protein (amino acids 200-401) was used as the immunogen for this antibody.
- Isotype:
- Mouse IgG2b Kappa
- Purification:
- Protein G Chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
