Monoclonal Antibody to Desmoglein 3 (Clone: ABM4A31)
Product Sizes
25ug
£319.00
10-7539-25UG
100ug
£429.00
10-7539-100UG
About this Product
- SKU:
- 10-7539
- Additional Names:
- DSG3||CDHF6
- translate.label.attr.clone:
- ABM4A31
- Clonality:
- Monoclonal
- Extra Details:
- DSG3 (Desmoglein 3) is a calcium-binding transmembrane glycoprotein component of desmosomes, conferring strong cell-cell adhesion. Desmosomes are button-like points of intercellular contact that allow the attachment of cytoskeletal elements to the plasma membrane at sites of cell-cell adhesion. DSG3 is expressed in basal and immediate suprabasal layers of skin. To maintain cell-cell adhesion DSG3 interacts with other desmosomal proteins, such as plakoglobin. Plakoglobin is closely related to Beta-catenin, which is a well-known downstream effector molecule in the canonical Wnt signaling pathway.DSG3 also promotes cancer cell growth and invasion through a plakoglobin-mediated signaling pathway.
- Format:
- Purified
- Gene Details:
- DSG3
- Host:
- Mouse
- Immunogen:
- A partial length recombinant Desmoglein 3 protein (amino acids 328-526) was used as the immunogen for this antibody.
- Isotype:
- Mouse IgG2b Kappa
- Purification:
- Protein G Chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
